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International Angelman Day is February 15

It was inspired, he said, by a work of art: “Boy with a Puppet” (or “A Child With a Drawing”) by Giovanni Francesco Caroto.

For English pediatrician Harry Angelman, the painting inspired his choice of the title, “Puppet Children,” to describe three children he had seen in his practice in 1965.

A Flash of Inspiration

As he described it:

“The history of medicine is full of interesting stories about the discovery of illnesses. The saga of Angelman's syndrome is one such story. It was purely by chance that nearly thirty years ago (e.g., circa 1964) three handicapped children were admitted at various times to my children's ward in England. They had a variety of disabilities and although at first sight they seemed to be suffering from different conditions I felt that there was a common cause for their illness. The diagnosis was purely a clinical one because in spite of technical investigations which today are more refined I was unable to establish scientific proof that the three children all had the same handicap. In view of this I hesitated to write about them in the medical journals. However, when on holiday in Italy I happened to see an oil painting in the Castelvecchio Museum in Verona called ... a Boy with a Puppet. The boy's laughing face and the fact that my patients exhibited jerky movements gave me the idea of writing an article about the three children with a title of Puppet Children. It was not a name that pleased all parents but it served as a means of combining the three little patients into a single group. Later the name was changed to Angelman syndrome. This article was published in 1965 and after some initial interest lay almost forgotten until the early eighties.”

From “Harry Angelman and the History of AS,” from the Angelman Syndrome Foundation

From Observance to Science

As Angelman noted, by the early 1980s more cases were being reported, with genetic research conducted later in the decade eventually identifying the chromosomal abnormality in approximately half of the children diagnosed with the syndrome.

Angelman syndrome (AS) causes developmental delay and neurological problems. It occurs in about 1 in 15,000 births. Currently there are approximately 490,000 people worldwide with AS.

At this time there is no cure.


Signs begin to appear between the ages of 6-12 months: difficulty with speech and movement, strabismus (where the eyes do not look toward the same object together), abnormal feeding, balance/motor issues.

The diagnosis of Angelman syndrome is based on:

Success Story

Alex: A LAMP Success Story: Like most children with Angelman Syndrome, Alex only communicated with natural gestures. Despite working with several different devices, he wasn’t able to maintain consistency. But once he received his Accent® with LAMP Words for Life®, it opened up a whole new world for Alex and his family.
Read the story


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